Current Studies
Crohn's Disease & Ulcerative Colitis
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Characterization of the Intestinal Microbiome in Patients with and without PSC
The objective is to assess the composition of the microbiome in patients with and without PSC, IBD patients without PSC (Ulcerative colitis and colonic Crohn’s disease) and healthy controls. -
Genetic Analysis of Infliximab-treated Inflammatory Bowel Disease Patients
Objective is to identify differentially expressed genes between responders and non-responders to Infliximab therapy and to examine if significant gene expression differences exist between Infliximab-treated Ulcerative colitis and Crohn’s Disease patients. -
The Identification of Genes for Inflammatory Bowel Disease
Objective is to identify new genes or biomarkers that may be responsible for causing Inflammatory Bowel Disease (IBD) and understand the role of previously identified genes in IBD. - Dietary Information (Food Diaries), Tissue (Biopsy) collections and Stool collections for IBD studiesObjective is to understand how diet and other biomarkers may affect the gut microbiome in IBD.
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The CCFC Michael J. Howorth GEM Project
To Identify why some individuals develop Crohn's Disease and others do not. This is accomplished by following healthy individuals considered to be at high risk for developing Crohn's disease over several years and measuring several factors before and after a diagnosis of Crohn's disease is made. -
The ENABLE Study (Equitability of Insurance Access to Biologics and its Impact on Effectiveness)
Objective is to formally assess the time interval from application for coverage of anti-TNF therapy (including Remicade and Humira) to first dose for privately vs. publicly insured patients with Inflammatory Bowel Disease (IBD) and to study whether potential delays in access to this therapy will have an effect on health outcomes such as hospitalization or surgery. -
Complementary
and Alternative Medicine (CAM): Prevalence and Longitudinal Impact on
Adherence to Conventional Therapy in Inflammatory Bowel Disease
Objective is to gain insight into the use complementary and alternative medicine (CAM) among patients with Inflammatory Bowel Disease (IBD), the different types of CAM, and perceived benefits of CAM that will help us better understand patients and potentially lead to better care. -
The SAFE Study (Survey on Awareness of Extraintestinal Inflammatory Bowel Disease)
Objective is to assess Inflammatory Bowel Disease patients' awareness of extra intestinal manifestations associated with Inflammatory Bowel Disease and inquire about where patients obtain their information on IBD. -
Barriers and Facilitators to medication compliance in IBD patients
The main aim of this study is to explore the perspectives of individuals with IBD in Toronto, Canada on barriers and facilitators to the compliance of medication.
Ulcerative colitis
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The UC Relapse Study: Gene expression profiles and microbial predictors of relapse in Ulcerative Colitis
To evaluate the genetic, microbial and other factors associated with remission and relapse in patients with Ulcerative Colitis (UC). -
Evolution of the Microbiome in a Pelvic Pouch Model: A Prospective Study to Understand Mechanisms of Ileal Inflammation
To examine the evolution of the microbiome in the pouch, and its association with pouch inflammation. -
Clinical Trial for a new medication in Ulcerative Colitis
Mount Sinai Hospital is participating in a research study to understand the safety and effectiveness of an investigational medication for treating Ulcerative colitis.
Crohn's Disease
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Clinical Trial for Perianal Fistulizing Crohn’s Disease
Mount Sinai Hospital is participating in a research study to understand the safety and effectiveness of a investigational medication for treating Crohn’s Disease with perianal fistulas. -
Clinical Trial for Small Bowel Crohn’s Disease
Mount Sinai Hospital is participating in a research study to understand the safety and effectiveness of a investigational medication for treating Crohn’s Disease affecting the small bowel. -
Mechanisms of Intestinal Inflammation Following Ileal Resection for Crohn's Disease
Objective is to evaluate microbial and gene expression factors which are associated with the recurrence of small bowel inflammation following surgery for Crohn’s Disease. This will have practical implications for evaluating which patients are more likely to rapidly recur as well as provide insight into the pathogenesis of Crohn’s Disease. -
Clinical Trial for a new medication in Crohn's Disease
Mount Sinai Hospital is participating in a research study to understand the safety and effectiveness of a investigational medication for treating Crohn’s Disease. -
Clinical Trial for a new medication in Crohn's Disease 2
Mount Sinai Hospital is participating in a research study to understand the safety and effectiveness of a investigational medication for treating Crohn’s Disease. -
Clinical Trial for a new oral medication in Crohn's Disease
Mount Sinai Hospital is participating in a research study to understand the safety and effectiveness of an investigational medication for treating Crohn’s Disease.