Zane Cohen Centre - Kenneth Croitoru

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Kenneth Croitoru | Gastroenterologist

Kenneth Croitoru, MDCM, FRCPC

2023croitoru ken Dr. Kenneth Croitoru joined the Division of Gastroenterology at Mount Sinai Hospital in January 2008. He completed medical school at McGill University in 1981 and trained in internal medicine and gastroenterology from 1982-1986. He did a post-doctoral MRC Research Fellowship in Mucosal Immunology with Dr. John Bienenstock at McMaster University. On completion of this research training he joined the Division of Gastroenterology at McMaster in 1992 where he went on to serve as Training Program Director and Associate Director of the Division. During this time, he developed his research program with funding from the Canadian Institute of Health Research, Canadian Association of Gastroenterology and the Crohn's and Colitis Foundation of Canada. He held an Ontario Ministry of Health Career Scientist award for 10 years and then a 5 year CCFC IBD Research Scientist Award. He served as the Chair of the CCFC Medical Advisory Board and helped develop the CCFC IBD Research Institute where he served as Chair of the Executive Committee until 2008.
Dr. Croitoru joined the Department of Medicine at Mount Sinai Hospital as a Clinician Scientist in 2008 and was appointed to the Lunenfeld-Tannenbaum Research Institute. He is also a full Professor of Medicine and Immunology at the University of Toronto, and a faculty member of the Institute of Medical Sciences.
His research is focused on investigating the fundamental mechanisms of intestinal inflammation, in particular the role of T cell effector and regulatory function in the intestinal mucosal in Inflammatory Bowel Disease (IBD). The goal of his work is to understand how T cells function to maintain intestinal homeostasis in health and what defects in regulatory T cells allow for the breakdown of these mechanisms.

Dr. Croitoru is also Project Leader of, the GEM Project (www.GEMPROJECT.ca) a global clinical study that is coordinated out of the IBD Research Group and Zane Cohen Center at Mount Sinai Hospital. The study is a prospective cohort study of healthy subjects at risk of developing Crohn's disease that explores the Genetic, Environmental and Microbial factors that lead to Cohn's disease. This study has had over $25 million in funding from Crohn's Colitis Canada, CIHR and the Helmsley Charitable Trust. Dr. Croitoru is a hold of a Canada Research Chair in IBD.

Centre
Mount Sinai Hospital
Zane Cohen Centre for Digestive Diseases
Inflammatory Bowel Diseases (IBD) Group

Contact
Phone: 416-586-4800 ext. 7454
Fax: 416-586-4747
Clinic E-mail: DrCroitoru.Clinic@sinaihealth.ca

Administrative Secretary
Alice Trinh
Phone: 416-586-4800 ext. 7454
Fax: 416-586-4747
E-mail: Alice.Trinh@sinaihealth.ca

Office Location
Mount Sinai Hospital
Joseph and Wolf Lebovic Health Centre
437-600 University Avenue
Toronto, Ontario, Canada
M5G 1X5

Board Certificates
Royal College Certificate in Internal Medicine and Gastroenterology
Specialist Certificate, Quebec, Internal Medicine and Gastroenterology
American Board of Internal Medicine Certification

Professional Organizations
American Gastroenterological Association
American Association of Immunologists
Canadian Association of Gastroenterology
Canadian Association for the Study of the Liver
Canadian Medical Association
Canadian Society for Immunology
Crohn’s and Colitis Foundation of Canada (Professional Member)
Ontario Association of Gastroenterology
Ontario Medical Association
Society for Mucosal Immunology

Publications (10 years)

Zanello, G., Goethel, A., Forster, K., Geddes, K., Philpott, D.J., Croitoru, K. Nod2 Activates NF-kB in CD4⁺ T cells but its Expression is Dispensable for T cell-Induced Colitis. PloS One 8(12):e82623, 2013.
Philpott, D.J., Sorbara, M.T., Robertson, S.J., Croitoru, K., Girardin S.E. NOD proteins: regulators of immunity in health and disease. Nature Reviews Immunology 14(1):9-23, 2014.
Smith, M.I., Turpin, W., Tyler, A.D., Silverberg, M.S., Croitoru, K. Microbiome analysis – from technical advances to biological relevance. F1000Prime Reports 6:51 eCollection, 2014.
Zanello, G., Kevans, D., Goethel, A., Silverberg, M., Tyler, A., Croitoru K. Genetics and Innate and Adaptive Immunity in IBD. Nestlé Nutrition Institute Workshop Series 79:41-55, 2014.
Hirsh, V., Blais, N., Burkes, R., Verma, S., Croitoru, K.Management of EGFR-TKI–Induced Diarrhea. Current Oncology 21(6):329-336, 2014.
Kevans, D., Turpin, W., Madsen, K., Meddings, J., Shestopaloff, K., Xu, W., Moreno-Hagelsieb, G., Griffiths, A., Silverberg, M.S., Paterson, A., Croitoru, K.; GEM Project. Determinants of intestinal permeability in healthy first-degree relatives of individuals with Crohn's disease. Inflammatory Bowel Diseases Journal 21(4):879-87, 2015.
Luck, H., Tsai, S., Chung, J., Clemente-Casares, X., Ghazarian, M., Revelo, X.S., Lei, H., Luk, C.T., Shi, S.Y., Surendra, A., Copeland, J.K., Ahn, J., Prescott, D., Rasmussen, B.A., Chng, M.H., Engleman, E.G., Girardin, S.E., Lam, T.K., Croitoru, K., Dunn, S., Philpott, D.J., Guttman, D.S., Woo, M., Winer, S., Winer, D.A. Regulation of Obesity-Related Insulin Resistance with Gut Anti-Inflammatory Agents. Cell Metabolism 21(4):527-42, 2015.
Benchimol, E.I., Manuel, D.G., To, T., Mack, D.R., Nguyen, G.C., Gommerman, J.L., Croitoru, K., Mojaverian, N., Wang, X., Quach, P., Guttmann, A. Asthma, Type 1 and Type 2 diabetes mellitus, and inflammatory bowel disease amongst South Asian immigrants to Canada and their children: a population-based cohort study. PLoS One 10(4): e0123599, 2015.
Malhi, G., Thanabalan, R., Croitoru, K., Silverberg, M., Steinhart, A.H., Nguyen, G. Vaccination in Inflammatory Bowel Disease Patients: Attitudes, Knowledge and Uptake. Journal of Crohn’s and Colitis 9(6):439-44, 2015.
Zittan, E., Kelly, O., Burns, J., Stempak, J., Nguyen, G., Croitoru, K., Van Assche, G., Silverberg, M.S., Steinhart, A.H. High Fecal Calprotectin Correlate with Active Colonic Disease but Not with Small Intestinal Crohn's Disease Activity. Gastroenterology, 2015 Apr; 148(4): S-448.
Murthy, S.K., Steinhart, A.H., Silverberg, M.S., Croitoru, K., Nguyen G.C., Greenberg G.R.Extent of Early Clinical Response to Infliximab Predicts Long-Term Treatment Success in Active Ulcerative Colitis.Inflammatory Bowel Diseases Journal, 2015 Sep; 21(9):2090-6.
Waterman, M., Knight, J., Dinani, J., Xu, W., Dinani, A., Stempack, J., Croitoru, K., Nguyen, G.C., Cohen, Z., McLeod, R.S., Greenberg, G.R., Steinhart, A.H., Silverberg, M.S. Predictors of Outcome in Ulcerative Colitis. Inflammatory Bowel Diseases Journal, 2015 Sep; 21(9):2097-105.
Kevans, D., Silverberg, M.S., Borowski, K., Griffiths, A., Xu, W., Onay, V., Paterson, A.D., Knight, J., Croitoru, K.; GEM Project. IBD Genetic Risk Profile in Healthy First-Degree Relatives of Crohn's Disease Patients. Journal of Crohn’s and Colitis. 2016 Feb; 10(2):209-15.
Zittan, E., Kelly, O.B., Kirsch, R., Milgrom, R., Burns, J., Nguyen, G.C., Croitoru, K., Van Assche, G., Silverberg, M.S., Steinhart, A.H. Low Fecal Calprotectin Correlates with Histological Remission and Mucosal Healing in Ulcerative Colitis and Colonic Crohn's Disease. Inflammatory Bowel Diseases Journal. 2016 Mar;22(3):623-30
Bodea, C.A., Neale, B.M., Ripke, S; International IBD Genetics Consortium, Daly, M.J., Devlin, B., Roeder, K. A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies. American Journal of Human Genetics. 2016 May 5;98(5):857-68
Zittan, E., Kabakchiev, B., Milgrom, R., Nguyen, G.C., Croitoru, K., Steinhart, A.H., Silverberg, M.S. Higher Adalimumab Drug Levels are Associated with Mucosal Healing in Patients with Crohn's Disease. Journal of Crohn’s and Colitis. 2016 May; 10(5):510-5.

Nguyen, G.C., Croitoru, K., Silverberg, M.S., Steinhart, A.H., Weizman, A.V. Use of Complementary and Alternative Medicine for Inflammatory Bowel Disease Is Associated with Worse Adherence to Conventional Therapy: The COMPLIANT Study. Inflammatory Bowel Diseases Journal. 2016 Jun;22(6):1412-7.
Zanello, G., Goethel, A., Rouquier, S., Prescott, D., Robertson, S.J., Maisonneuve, C., Streutker, C., Philpott, D.J., Croitoru, K. The Cytosolic Microbial Receptor Nod2 Regulates Small Intestinal Crypt Damage and Epithelial Regeneration following T Cell-Induced Enteropathy. The Journal of Immunology. 2016 Jul; 197(1):345-55.
Rivas, M.A., Graham, D., Sulem, P., Stevens, C., Desch, A.N., Goyette, P., Gudbjartsson, D., Jonsdottir, I., Thorsteinsdottir, U., Degenhardt, F., Mucha, S., Kurki, M.I., Li, D., D'Amato, M., Annese, V., Vermeire, S., Weersma, R.K., Halfvarson, J., Paavola-Sakki, P., Lappalainen, M., Lek, M., Cummings, B., Tukiainen, T., Haritunians, T., Halme, L., Koskinen, L.L., Ananthakrishnan, A.N., Luo, Y., Heap, G.A., Visschedijk, M.C.; UK IBD Genetics Consortium; NIDDK IBD Genetics Consortium, MacArthur, D.G., Neale, B.M., Ahmad, T., Anderson, C.A., Brant, S.R., Duerr, R.H., Silverberg, M.S., Cho, J.H., Palotie, A., Saavalainen, P., Kontula, K., Färkkilä, M,, McGovern, D.P., Franke, A., Stefansson, K., Rioux, J.D., Xavier, R.J., Daly, M.J., Barrett, J., de Lane, K., Edwards, C., Hart, A., Hawkey, C., Jostins, L., Kennedy, N., Lamb, C., Lee, J., Lees, C., Mansfield, J., Mathew, C., Mowatt, C., Newman, B., Nimmo, E., Parkes, M., Pollard, M., Prescott, N., Randall, J., Rice, D., Satsangi, J., Simmons, A., Tremelling, M., Uhlig, H., Wilson, D., Abraham, C., Achkar, J.P., Bitton, A., Boucher, G., Croitoru, K., Fleshner, P., Glas, J., Kugathasan, S., Limbergen, J.V., Milgrom, R., Proctor, D., Regueiro, M., Schumm, P.L., Sharma, Y., Stempak, J.M., Targan, S.R., Wang, M.H. A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis. Nature Communications. 2016 Aug 9; 7(1), 1-8. https://doi.org/10.1038/ncomms12342
Zittan, E., Milgrom, R., Ma, G.W., Wong-Chong, N., O?Connor, B., McLeod, R.S., MacRae, H.M., Greenberg, G.R., Nguyen, G.C., Croitoru, K., Steinhart, A.H., Cohen, Z., Silverberg, M.S. Preoperative Anti-tumor Necrosis Factor Therapy in Patients with Ulcerative Colitis Is Not Associated with an Increased Risk of Infectious and Noninfectious Complications After Ileal Pouch-anal Anastomosis. Inflammatory Bowel Diseases Journal. 2016 Oct; 22(10), 2442-2447. https://doi.org/10.1097/MIB.0000000000000919
Turpin, W., Espin-Garcia, O., Xu, W., Silverberg, M.S., Kevans, D., Smith, M.I., Guttman, D.S., Griffiths, A., Panancionne, R., Otley, A., Xu, L., Shestopaloff, K., Moreno-Hagelsieb, G., The GEM Project Research Consortium, Paterson, A.D., Croitoru, K. Association of Host Genome with Intestinal Microbial Composition in a Large Healthy Cohort. Nature Genetics. 2016 Nov; 48(11):1413-1417. https://doi.org/10.1038/ng.3693
Zittan, E., Kabakchiev, B., Kelly, O.B., Milgrom, R., Nguyen, G.C., Croitoru, K., Steinhart, A.H., Silverberg, M.S. Development of the Harvey-Bradshaw Index-pro (HBI-PRO) Score to Assess Endoscopic Disease Activity. Crohn’s Disease Journal of Crohn's and Colitis. 2016 Dec; 6 jjw200. doi: 10.1093/ecco-jcc/jjw200. https://doi.org/10.1038/ng.3693
Rumman, A., Candia, R., Sam, J., Croitoru, K., Silverberg, M., Steinhart, H., Nguyen, G.C. Public versus private drug insurance and outcomes of patients requiring biologic therapies for inflammatory bowel disease. Canadian Journal of Gastroenterology and Hepatology. 2017 Jan; 2017(Article ID 7365937). https://doi.org/10.1155/2017/7365937
Turpin, W., Bedrani, L., Espin-Garcia, O., Xu, W., Silverberg, M.S, Smith, M.I., Guttman, D., Griffiths, A., Moayyedi, P., Panaccione, R., Huynh, H., Steinhart, H., Aumais, G., Shestopaloff, K.,Dieleman, L.A., Turner, D., CCC IBD GEM Project research team, Paterson, A.D., Croitoru, K. FUT2 genotype and secretory status are not associated with fecal microbial composition and inferred function in healthy subjects. Gut Microbes. 2018 Feb; 1-12. 9(4), 357-368. https://doi.org/10.1080/19490976.2018.1445956
Turpin, W., Goethel, A., Bedrani, L., Croitoru, K. Determinants of IBD heritability: genes, bugs and more. Inflammatory Bowel Diseases. 2018 March; 24(6): 1133-1148. https://doi.org/10.1093/ibd/izy085

Liu, J., Nicum, S., Reichardt, P., Croitoru, K., Illek, B., & Schmidinger, M., Rogers, C., Whalen, C., Jayson, G. Assessment and management of diarrhea following VEGF receptor TKI treatment in patients with ovarian cancer. Gynecologic Oncology. 2018 April; 150(1), 173-179. https://doi.org/10.1016/j.ygyno.2018.03.058
Goethel, A., Croitoru, K., & Philpott, D. The interplay between microbes and the immune response in inflammatory bowel disease. J Physiol. 2018 May 28; 596(17), 3869-3882. doi: 10.1113/JP275396.
Wang, J., Kurilshikov, A., Radjabzadeh, D., Turpin, W., Croitoru, K., & Bonder, M. Jackson, M., Medina-Gomez, C., Frost, F., Homuth, G., Rühlemann, M., Hughes, D., MiBioGen Consortium Initiative (2018), Timpson, N., Franke, A., Wijmenga, C., Meyer, K., Kacprowski, T., Franke, L., Paterson, A.D., Raes, J., Kraaij, R., Zhernakova, A. Meta-analysis of human genome-microbiome association studies: The MiBioGen consortium initiative. Microbiome. 8 June 2018: 6(1). doi: 10.1186/s40168-018-0479-3
Zezos, P., Kabakchiev, B., Weizman, A. V., Nguyen, G. C., Narula, N., Croitoru, K., Steinhart, A. H. & Silverberg, M. S. (2018). Ulcerative Colitis Patients Continue to Improve Over the First Six Months of Vedolizumab Treatment: 12-Month Clinical and Mucosal Healing Effectiveness. Journal of the Canadian Association of Gastroenterology, 3(2), 74-82. doi: 10.1093/jcag/gwy065
Radhakrishnan, D., Guttmann, A., To, T., Reisman1, J.J., Knight, B.D., Mojaverian, N., Manuel, D.G., Gommerman, J.L., Croitoru, K., Benchimol, E.I. Generational patterns of asthma incidence among immigrants to Canada over two decades: A population-based cohort study. Annals of the American Thoracic Society, 2019 Feb; 16(2) 248-257. doi: 10.1513/AnnalsATS.201803-187OC.
Weizman, A.V., Sharma, R., Afzal, N.M., Xu, W., Walsh, S., Stempak, J.M., Nguyen, G.C., Croitoru, K., Steinhart, A.H., Silverberg, M.S. Stricturing and Fistulizing Crohn’s Disease Is Associated with Anti-tumor Necrosis Factor-Induced Psoriasis in Patients with Inflammatory Bowel Disease. Digestive Diseases and Sciences. 2018; 63 (9), 2430-2438. https://doi.org/10.1007/s10620-018-5096-2
Espin-Garcia, O., Croitoru, K., Xu, W. A Finite Mixture Model for X-Chromosome Association with Emphasis on Microbiome Data Analysis. Genet. Epidemiol. 2019 Jan 18; 43(4), 427-439. doi:
Goethel, A., Turpin, W., Rouquier, S., Zanello, G., Robertson, S.J., Streutker, C., Philpott, D.J., Croitoru, K. Nod2 Influences Microbial Resilience and Susceptibility to Colitis Following Early Life Antibiotic Exposure. Mucosal Immunology. 2019 Jan 16; 12(3), 720-732. doi: 10.1038/s41385-018-0128-y
Tandon, P., Huang, V., Jaffer, N., Kirsch, R., Croitoru, K. A Rare Presentation of Hypovolemic Shock Secondary to Whipple’s Disease. Eur J Gastroenterol Hepatol. 2019 Jan 28; 31(5), 642-645.doi: 10.1097/MEG.0000000000001363
Robertson, S., Lemire, P., Maughan, H., Goethel, A., Turpin, W., Bedrani, L., Croitoru, K., Girardin, S., Philpott, D.,Comparison of co-housing and littermate methods for microbiota standardization in mouse models.Cell Reports. 2019 May 7; 27(6), 1910-1919.e2.doi: 10.1016/j.celrep.2019.04.023.
Turpin, W., Kelly, O., Borowski, K., Boland, K.,Tyler, A., Cohen, Z., Croitoru, K., Silverberg, M. Mucosa associated microbiota in ileoanal pouches may contributes to clinical symptoms, particularly stool frequency, independent of endoscopic disease activity. Clinical and Translational Gastroenterology. 2019 May 22; 10(5).doi: 10.14309/ctg.0000000000000038.
Turpin, W., Espin-Garcia, O., Bedrani, L., Madsen, K., Meddings, J., Raygoza Garay, J., Silverberg, M., Smith, M., Griffiths, A., Moayyedi, P., Marshall, J., Mack, D., Seidman, E., Ropeleski, M., Feagan, B., Jacobson, K., Turner, D., Walters, T., Paterson, A.; CCC GEM Project Research Consortium, Xu, W., Croitoru, K.Analysis of Genetic Association of Intestinal Permeability in Healthy First-degree Relatives of Patients with Crohn's Disease. Inflammatory Bowel Disease. 2019 Jun 28; 25(11), 1796-1804.doi: 10.1093/ibd/izz116
Ho, S., Lewis, J., Mayer, E., Plevy, S., Chuang,E., Rappaport, S., Croitoru, K., Korzenik, J., Krischer, J., Hyams, J., Judson, R., Kellis, M., Jerrett, M., Miller, G., Grant, M., Shtraizent, N., Honig, G., Hurtado-Lorenzo, A., Wu, G. Challenges in IBD Research: Environmental Triggers. IBD Journal, June 2019; 25(S2), S13-S23.
Romagnoni, A., Jégou, S., Van Steen, Wainrib, G., Hugot, JP. Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data. Scientific Reports. 2019 Jul 17; 9(1), 1-18. doi: 10.1038/s41598-019-46649-z.
Boland, K., Greener, T., Kabakchiev, B., Stempak, J.Tessolini, J., Li, R., Soriano, J., Croitoru, K., Nguyen, G., Steinhart, A.H., Weizman, A., Silverberg, M. Identification of target golimumab levels in maintenance therapy of Crohn’s disease and ulcerative colitis associated with mucosal healing, IBD J.17 September 2019; 26(5), 766-773. https://doi.org/10.1093/ibd/izz199
Boland, K., Bedrani, L, Turpin, W., Kabakchiev, B., Stempak, J., Borowski, K., Nguyen, G., Steinhart, A.H., Smith, M., Croitoru, K., Silverberg, M.S. Persistent Diarrhea in Patients With Crohn's Disease After Mucosal Healing Is Associated With Lower Diversity of the Intestinal Microbiome and Increased Dysbiosis.Clin Gastroenterol Hepatol. 2020 Mar 24; 19(2), 296-304. doi: 10.1016/j.cgh.2020.03.044.
Turpin, W., Lee, S.H., Raygoza Garay, J.A., Madsen, K.L., Meddings, J.B., Bedrani, L., Power, N., Espin-Garcia, O., Xu, W., Smith, M.I., Griffiths, A.M., Moayyedi, P., Turner, D., Seidman, E.G., Steinhart, H.A., Marshall, J.K., Jacobson, K., Mack, D., Huynh, H., Bernstein, C.N., Paterson, A.D., Croitoru, K.; CCC GEM Project Research Consortium. Increased Intestinal Permeability is Associated with Later Development of Crohn's Disease, Gastroenterology. 2020 Dec; 159(6), 2092-2100. doi:10.1053/j.gastro.
Turpin, W. Bedrani, L., Espin-Garcia, O., Xu, W., Silverberg, M.S., Smith, M.I., Raygoza Garay, J.A., Lee, S.H., Guttman, D.S., Griffiths, A., Moayyedi, P., Panaccione, R., Huynh, H., Steinhart, H.A., Aumais, G., Dieleman, L.A., Turner, D., Paterson, A.D., Croitoru,K. Associations of NOD2 polymorphisms with Erysipelotrichaceae in stool of in healthy First Degree Relatives of Crohn’s Disease subjects. BMC Medical Genetics. 2020 Oct 15; 21(1), 1-8. https://doi.org/10.1186/s12881-020-01115-w.
Irrazabal, T., Thakur, B. K., Croitoru, K. & Martin, A. Preventing Colitis-associated Colon Cancer with antioxidants: A systematic Review. Cellular and Molecular Gastroenterology and Hepatology. 2021 Jan 5; 11(4), 1177-1197. https://doi.org/10.1016/j.jcmgh.2020.12.013.
Kurilshikov, A., Medina-Gomez, C., Bacigalupe, R., Radjabzadeh, D., Wang, J., Demirkan, A., Le Roy, C. I., Raygoza Garay J. A., Finnicum, C. T., Liu, X., Zhernakova, D.V., Bonder, M. J., Hansen, T. H., Frost, F., Ruhlemann, M. C., Turpin, W., Moon, J., Kim, H., Lull, K., Barkan, E., Shah, S. A., Fornage, M., Szopinska-Tokov, J., Wallen, Z. D., Borisevich, D., Agreus, L., Andreasson, A., Bang, C., Bedrani, L., Bell, J. T., Bisgaard, H., Boehnke, M., Boomsma, D. I., Burk, R.D., Claringbould, A., Croitoru, K., Davies, G. E., Van Duijn, C. M., Duijts, L., Falony, G., Fu, J., Van der Graaf, A., Hansen, T., Homuth, G., Hughes, D. A., Ijzerman, R. G., Jackson, M. A., Jaddoe, V. W. V., Joossens, M., Jorgensen, T., Keszthelyi, D., Knight, R., Laakso, M., Laudes, M., Launer, L. J., Lieb, W., Lusis, A. J., Masclee, A. A. M., Moll, H. A., Mujagic, Z., Qibin, Q., Rothschild, D., Shin, H., Sorensen, S. J., Steves, C. J., Thorsen, J., Timpson, N. J., Tito, R. Y., Vieira-Silva, S., Volker, U., Volzke, H., Vosa, U., Wade, K. H., Walter, S., Watanabe, K., Weiss, S., Weiss, F. U., Weissbrod, O., Westra, H., Willemsen, G., Payami, H., Jonkers, D. M. A. E., Arias Vasquez, A., De Geus, E. J. C., Meyer, K. A., Stokholm, J., Segal, E., Org, E., Wijmenga, C., Kim, H., Kaplan, R. C., Spector, T. D., Uitterlinden, A. G., Rivadeneira, F., Franke, A., Lerch, M. M., Franke, L., Sanna, S., D’Amato, M., Pedersen, O., Paterson, A. D., Kraaij, R., Raes, J., Zhernakova, A. Large-scale association analyses identify host factors influencing human gut microbiome composition. Nature Genetics. 2021 Jan 18; 53, 156-165. https://doi.org/10.1038/s41588-020-00763-1.
Copeland, J. K.,Chao, G., Vanderhout, S., Acton, E., Wang, P. W., Benchimol, E. I., Sohami, A. E., Croitoru, K., Gommerman, J. L., Guttman, D. S., & the GEMINI Research Team. The Impact of Migration on the Gut Metagenome of South Asian Canadians. Gut Microbes. 2021 Jan; 13(1), 1-29. doi: 10.1080/19490976.2021.1902705.
Power, N., Turpin, W., Espin-Garcia, O., Smith, M. I., The CCC GEM Project Research Consortium, Croitoru, K. Serum zonulin measured by commercial kit fails to with physiologic measures of altered gut permeability in first degree relatives of Crohn’s disease patients. Frontiers in Physiology. 2021 Mar 25; 12, 334. doi: 10.3389/fphys.2021.645303.
Galipeau HJ, Caminero A, Turpin W, Bermudez-Brito M, Santiago A, Libertucci J, Constante M, Raygoza Garay JA, Rueda G, Armstrong S, Clarizio A, Smith MI, Surette MG, Bercik P; CCC Genetics, Environmental, Microbial Project Research Consortium, Croitoru K, Verdu EF. Novel Fecal Biomarkers That Precede Clinical Diagnosis of Ulcerative Colitis. Gastroenterology. 2021 Apr;160(5):1532-1545. doi: 10.1053/j.gastro.2020.12.004. Epub 2020 Dec 10.

Lee SH, Turpin W, Espin-Garcia O, Raygoza Garay JA, Smith MI, Leibovitzh H, Goethel A, Turner D, Mack D, Deslandres C, Cino M, Aumais G, Panaccione R, Jacobson K, Bitton A, Steinhart AH, Huynh HQ, Princen F, Moayyedi P, Griffiths AM, Silverberg MS, Paterson AD, Xu W, Croitoru K; Crohn’s and Colitis Canada Genetics Environment Microbial Project Research Consortium. Anti-Microbial Antibody Response is Associated With Future Onset of Crohn's Disease Independent of Biomarkers of Altered Gut Barrier Function, Subclinical Inflammation, and Genetic Risk. Gastroenterology. 2021 Jul 20:S0016-5085(21)03243-1. doi: 10.1053/j.gastro.2021.07.009. Epub ahead of print.
Torres J, Halfvarson J, Rodríguez-Lago I, Hedin CR, Jess T, Dubinsky M, Croitoru K, & Colombel J-F. Results of the Seventh Scientific Workshop of ECCO: Precision Medicine in IBD—Prediction and Prevention of Inflammatory Bowel Disease. Journal of Crohn's and Colitis. 2021 Mar; 15(9): 1443–1454. https://doi.org/10.1093/ecco-jcc/jjab048
Currie E, Coburn B, Porfilio EA, Lam P, Rojas OL, Novak J, Yang S, Chowdhury R, Ward LA, Wang PW, Khaleghi K, An J, Crome SQ, Hladunewich MA , Barbour SJ, Cattran DC, Parekh RS, Licht C, John, R, Kaul R, Croitoru K, Gray-Owen SD, Guttman DS, Gommerman JL and Reich HN.Immunoglobulin A Nephropathy is characterized by anti-commensal humoral immune responses. J Clinical Investigation, Insight,Mar 8, 2022;7(5):e141289. doi: 10.1172/jci.insight.141289.PMID: 35133979.
Turpin W, Dong M, Sasson G, Raygoza Garay JA, Espin-Garcia O, Lee SH, Neustaeter A, Smith MI, Leibovitzh H, Guttman DS, Goethel A, Griffiths AM, Huynh HQ, Dieleman LA, Panaccione R, Steinhart AH, Silverberg MS, Aumais G, Jacobson K, Mack D, Murthy SK, Marshall JK, Bernstein CN, Abreu MT, Moayyedi P, Paterson AD; Crohn’s and Colitis Canada (CCC) Genetic, Environmental, Microbial (GEM) Project Research Consortium, Xu W, Croitoru K. Mediterranean-Like Dietary Pattern Associations With Gut Microbiome Composition and Subclinical Gastrointestinal Inflammation.Gastroenterology. 2022 Sep;163(3):685-698. doi: 10.1053/j.gastro.2022.05.037.
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