Why do some people with PJS develop cancer?

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There is an increased risk for cancer, either in the tissue of a hamartoma or an adenoma, within the gastrointestinal tract. For women with PJS, a somewhat increased chance of developing cancer of the breast, ovaries, or cervix has been reported.

For men, cancer of the testis has been observed slightly more frequently than in the general population . Cancer of the pancreas may also occur. This does not mean that everyone with PJS will develop cancer. It is important to be alert for symptoms such as ongoing abdominal pain, intestinal bleeding, yellowing of the skin, or unexplained tiredness. A blood test can be done to check the hemoglobin every year to ensure that anemia is not present.

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