Characterization of the Intestinal Microbiome in Patients with and without PSC


Details of Research

Contact: Joanne Stempak, Project Manager
416-586-4800 ext 8399

Primary Investigator:
Mark Silverberg, MD
Enrolment: Ongoing

The objective is to assess the composition of the microbiome in patients with and without PSC, IBD patients without PSC (Ulcerative colitis and colonic Crohn’s disease) and healthy controls.

This research may lead to a better understanding of why the disease occurs and what role the gut microbiome and other markers play in PSC and/or IBD.

Eligibility: Anyone who has a confirmed diagnosis of Primary Sclerosing Cholangitis and/or IBD (either Crohn's Disease or Ulcerative Colitis). Also, if you do not have IBD (i.e. Crohn's Disease or Ulcerative colitis) and do not have a family history of IBD and are willing to participate as a healthy control, your help would be greatly appreciated.


  • Participation involves:
    • Providing us with information regarding your family history and disease specifics
    • A small blood sample for research purposes
    • Providing us with permission to review your medical information regarding IBD
    • Filling in a 4-day food diary prior to your sample collection
    • If you are scheduled to have a colonoscopy already as part of your routine clinical care, you may be asked if you're willing to provide tissue biopsies for research purposes during your colonoscopy
    • If you are willing, you may be asked to provide a stool sample which can be collected at home
  • All study supplies are provided by us.
  • You may not have to see any physicians at Mount Sinai Hospital, if you are not already scheduled to have a colonoscopy performed by your physician.

We would like to sincerely thank all of our study participants. This research couldn't be possible without your cooperation.

Please contact Joanne Stempak (phone 416-586-4800 x8399) if you are interested in participating in this study.

Donate to the Zane Cohen Centre
Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex. Copyright © 1997 - 2017.
All Rights Reserved. A patient care, teaching and research centre affiliated with University of Toronto.
Powered by Joomla 1.7 Templates