A graduate of Queen’s University Medical School, Dr. Gladdy entered the General Surgery Training Program at The University of Toronto in 1996. During her general surgery training, she undertook research studies as a graduate student in cancer genetics at The University of Toronto, and received her Ph.D. in Molecular Biology in 2003. She became a Fellow of the Royal College of Physicians and Surgeons of Canada in 2005. After a Clinical Fellowship in Surgical Oncology at Memorial Sloan-Kettering Cancer Center in New York City, NY, she began her Surgical Oncology Staff Appointment at Mount Sinai and Princess Margaret Hospitals in 2008.

Dr. Gladdy is currently an Assistant Professor in the Department of Surgery at The University of Toronto. Her clinical practice is focused on the management of soft tissue sarcomas and GI cancers. Dr. Gladdy is also a Clinician-Scientist at the Ontario Institute for Cancer Research (OICR) and her research laboratory is at Samuel Lunenfeld Research Institute at Mount Sinai Hospital where she is currently conducting research in the genetics of sarcoma.

Centre
Mount Sinai Hospital
Zane Cohen Centre for Digestive Diseases (ZCC)
Soft Tissue Sarcoma Research Program (STSRP)

Mailing Address
Samuel Lunenfeld Research Institute
1070B-600 University Avenue
Toronto, Ontario
Canada, M5G 1X5

Mailing Address (Clinical Office)
Mount Sinai Hospital
1225-600 University Avenue
Toronto, Ontario
Canada, M5G 1X5

Publications

• Gladdy RA, Qin L, Moraco N, Edgar MA, Antonescu CR, Alektiar K , Brennan MF and Singer S. Do radiation associated soft tissue sarcomas have the same prognosis as sporadic soft tissue sarcomas? Journal of Clinical Oncology. In press.

• Matei IR, Gladdy RA, Nutter LMJ, Guidos CJ and JS Danska. ATM deficiency disrupts TCRalocus integrity and the maturation of CD4+CD8+thymocytes. Blood. 2007;109(5):1887-1996.

• Gladdy RA, Nutter LMJ, Kunath T, Danska JS and CJ Guidos. p53-Independent Apoptosis Disrupts Early Organogenesis in Embryos Lacking Both ATM and Prkdc. Mol Cancer Res. 2006;4(5):311-8.

• Khalifa MA, Rowsell CH, Gladdy RA, Ko JY, Hanna S, Smith AJ, and C Law. Immunohistochemical Assessment of Epidermal Growth Factor Receptor in Primary Colorectal Adenocarcinoma as a Predictor of Recurrence. 2006;125:1-5. American Journal of Clinical Pathology.

• Gladdy RA, Taylor MD, Williams CJ, Rutka JT, Karaskova J, Squire J, Guidos CJ and Danska JS. The RAG-1/2 endonuclease causes genomic instability and controls CNS complication of lymphoblastic leukemia in p53/Prkdc-deficient mice. Cancer Cell. 2003;3:37-50.